ea0015p161 | Diabetes, metabolism and cardiovascular | SFEBES2008
Brown Russell E
, Wilkinson Paul MH
, Imran Syed A
, Ur Ehud
, Wilkinson Michael
Aims/hypothesis: Resistin could be implicated in the mechanism of insulin resistance and recent evidence suggests this occurs, in part, via a brain-dependent pathway. Given the emerging role of hypothalamic AMP-activated protein kinase (AMPK) in the modulation of appetite and glucose levels, we hypothesized that its activity would be modulated by resistin. To verify such a pathway, we employed the N-1 hypothalamic neuronal cell line, which expresses a variety of neuropeptides ...